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KMID : 0365819880280020115
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Journal of Pusan Medical College
1988 Volume.28 No. 2 p.115 ~ p.122
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Experimental study on the Effect of Magnitude of Monopolar Coagulation in Rabbit Basal Ganglia
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Abstract
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The monopolar coagulation lesions were generated by various magnitude in rabbit basal ganglia (head of caudate nucleus and putamen).
The microscopic features and extents of lesions with Evans blue and hematoxylin-eosin stain were observed.
The results were as follows
1. Microscopically, the lesions were characterized by ground substance depigmentation, vacuolization and neural damage with pyknotic nuclei and loss of detail. In section of the coagulation sites stained with Evans blue, the lesion was demarcated with blue-green discoloration of the parenchyma and superficial cortical necrosis was showed. The surface lesion of basal ganglia in various sections appeared nearly round and wedged shape.
2. Radius of cut surface of lateral margin of lesion on the basal ganglia was proportionally increased with the increase of magnitude of electric coagulation by both stains and the radius of lesion with H -E stain was not significantly increased than that with Evans blue.
3. The distance between the coagulation site and the center of cut surface of lateral margin of lesion on the basal ganglia, the distance between the center of cut surface of lateral margin of lesion on the basal ganglia and the deepest portion of lesion were proportionally increased with to increase of magnitude of electric coaguation by both stains, and the distance with H-E stain was not significant increased than that with Evans blue.
4. Cross section of basal ganglia lesion with both stains was proportionally increased with the increase of magnitude of electric coagulation by both stains, and also the caws section with H-E stain was not significantly increased than with Evans blue.
The results suggest that basal ganglia damage resulting from electric coagulation might be due to the bloodbrain barrier dysfunction by thermal origin. The extents of lesion were proportionally increased with the increase of magnitude of electrical coagulation
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